I know that you're all probably like "duh!!!" but seriously, I didn't really think it would be bad, at least not for me. I have never been one to become drowsy from medication, not even Benadryl, so when I bought Nyquil (pills) and Tylenol PM I didn't think it would be bad! And no, I didn't read the labels! I just know that when I get a sore throat it is really hard for me to fall asleep and I wanted to get a good night's rest in. So on Friday I took 2 of each and I went to bed. I ended up waking up like at 12 pm the next day and I was completely slow! LOL! I remember waking up a little earlier than that and thinking about how swollen my face felt (although it wasn't actually swollen), like when the dentists injects you with anesthesia! And it was really hard to move, like if my brain was sending signals to my arms and stuff to move, but they couldn't or wouldn't! And I spent the rest of the day in bed letting the pills wear off. Then on Saturday I decided to just take the 2 Nyquil pills alone and I woke up at 3 pm on Sunday. Then last night I was too afraid to take any of them because I didn't want to not show up for work today so I tried falling asleep without anything and couldn't. So I took 1 Nyquil pill and that did the trick! I woke up at 7: 30 this morning and made it to work on time! YAY! LOL! So anyway, boys and girls, do not mix Nyquil and Tylenol PM!!!! Not a good idea! :)